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| Ferreira,Paulo Roberto Abrão; Brandão-Mello,Carlos Eduardo; Estes,Chris; Gonçales Júnior,Fernando Lopes; Coelho,Henrique Sérgio Moraes; Razavi,Homie; Cheinquer,Hugo; Wolff,Fernando Herz; Ferraz,Maria Lúcia Gomes; Pessoa,Mário Guimarães; Mendes-Correa,Maria Cássia. |
| Background: Hepatitis C virus infection is a major cause of cirrhosis; hepatocellular carcinoma; and liver transplantation. The aim of this study was to estimate hepatitis C virus disease progression and the burden of disease from a nationwide perspective.Methods: Using a model developed to forecast hepatitis C virus disease progression and the number of cases at each stage of liver disease; hepatitis C virus-infected population and associated disease progression in Brazil were quantified. The impact of two different strategies was compared: higher sustained virological response and treatment eligibility rates (1) or higher diagnosis and treatment rates associated with increased sustained virological response rates (2).Results: The number of infected... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HCV; Disease burden; Epidemiology; Incidence; Brazil. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400363 |
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| Weissmann,Leonardo; Picone,Camila de Melo; Gouvêa,Michele Soares Gomes; Ferreira,Paulo Roberto Abrão; Viana,Mônica Salum Valverde Borsoi; Pinho,João Renato Rebello; Cassenote,Alex Jones Flores; Segurado,Aluísio Cotrim. |
| ABSTRACT Background: Antiretroviral therapy (ART) has decreased AIDS incidence and mortality, rendering comorbidities, such as hepatitis B more relevant for people living with human immunodeficiency virus (HIV). Since antiretroviral drugs may also inhibit hepatitis B virus (HBV) replication, analyzing the impact of ART on management of hepatitis B in this population is important. Objective: To assess HBV viremia among HIV/HBV coinfected individuals on ART and its associated factors. Method: For this cross-sectional study, HIV/HBV-coinfected individuals, aged over 18 years, who were on ART for over six months and receiving care at an outpatient clinic in São Paulo were recruited. Sociodemographic characteristics, information about viral exposure,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV infections Hepatitis B Coinfection Antiretroviral agents Viremia DNA; Viral. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600441 |
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| Benzaken,Adele Schwartz; Girade,Renato; Catapan,Elisa; Pereira,Gerson Fernando Mendes; Almeida,Elton Carlos de; Vivaldini,Simone; Fernandes,Neide; Razavi,Homie; Schmelzer,Jonathan; Ferraz,Maria Lucia; Ferreira,Paulo Roberto Abrão; Pessoa,Mario Guimarães; Martinelli,Ana; Souto,Francisco José Dutra; Walsh,Nick; Mendes-Correa,Maria Cassia. |
| ABSTRACT Introduction and aim: Hepatitis C is a key challenge to public health in Brazil. The objective of this paper was to describe the Brazilian strategy for hepatitis C to meet the 2030 elimination goal proposed by World Health Organization (WHO). Methods: A mathematical modeling approach was used to estimate the current HCV-infected Brazilian population, and to evaluate the relative costs of two different scenarios to address HCV disease burden in Brazil: (1) if no further changes are made to the HCV treatment program in Brazil; (2) where the WHO targets for 2030 elimination are met through diagnosis and treatment efforts peaking before 2024. Results: An anti-HCV prevalence of 0.53% was calculated for the total population. It was estimated that the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C; Hepatitis C elimination; Hepatitis C disease burden; Brazil. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300182 |
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| Ferreira,Paulo Roberto Abrão; Silva,Mariliza Henrique da; Brandão-Melo,Carlos Eduardo; Rezende,Rosamar Eulira; Gonzalez,Mário; Reuter,Tânia; Urbaez,Jose David; Gianini,Reinaldo Jose; Martinelli,Ana; Mendes-Correa,Maria Cássia. |
| Introduction: in Brazil, chronic hepatitis C in patients coinfected with the human immunodeficiency virus (HIV) is treated with pegylated interferon (Peg-IFN) and ribavirin (RBV). However, few studies have evaluated the effectiveness of this treatment in this particular population. The identification of the factors that predict sustained virological response (SVR) under current clinical practice would enable clinicians to more accurately estimate the probability of achieving an SVR and therefore utilize the appropriate therapeutics, especially in the era of direct-acting antiviral (DAA) agents.Aims: the primary aim of our study was to determine the SVR rate under current clinical practice. The secondary aims were as follows: (1) to determine the factors... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Interferon Ribavirin HCV; HIV. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100015 |
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